地 点： 基础部十楼1009会议室
1. 宋越 2008级硕士研究生 导师： 李青 教授
题 目：Chronic high-fat diet in fathers programs b-cell dysfunction in female rat offspring
The global prevalence of obesity is increasing across most ages in both sexes. This is contributing to the early emergence of type 2 diabetes and its related epidemic1,2. Having either parent obese is an independent risk factor for childhood obesity3. Although the detrimental impacts of diet-induced maternal obesity on adiposity and metabolism in offspring are well established4, the extent of any contribution of obese fathers is unclear, particularly the role of non-genetic factors in the causalpathway.Hereweshowthat paternal high-fat-diet (HFD) exposure programs b-cell ‘dysfunction’ in rat F1 female offspring. ChronicHFDconsumption in Sprague–Dawley fathers induced increased body weight, adiposity, impaired glucose tolerance and insulin sensitivity. Relative to controls, their female
offspring had an early onset of impaired insulin secretion and glucose tolerance that worsened with time, and normal adiposity. Paternal HFD altered the expression of 642 pancreatic islet genes in adult female offspring (P ,0.01); genes belonged to 13 functional clusters, including cation and ATP binding, cytoskeleton and intracellular transport. Broader pathway analysis of 2,492 genes differentially expressed (P ,0.05) demonstrated involvement of calcium-, MAPK- and Wnt-signalling pathways, apoptosis and the cell cycle. Hypomethylation of the Il13ra2 gene, which showed the highest fold difference in expression (1.76-fold increase), was demonstrated. This is the first report in mammals of non-genetic, intergenerational transmission of metabolic sequelae of a HFD from father to offspring.
2. 肖永春 2008级硕士研究生 导师： 黄高昇 教授
题 目：Histologic Classification of Thymoma: The World Health Organization and Beyond
The histologic classification of primary thymic epithelial neoplasms has been the source of difficulties for many years and was approached in the past in several different ways by various investigators. A number of histologic classification schemes have been proposed over the years, of which none has yet been able to resolve the problems involved in the evaluation of these tumors. Historically, the histologic classification that gained the greatest acceptance, particularly in the United States, was the ‘‘traditional’’ classification proposed by Bernatz and colleagues  from the Mayo Clinic. These investigators divided thymomas histologically on the basis of their relative proportion of epithelial cells to lymphocytes and the shape of the tumor cells. Their classification recognized four basic types of thymoma: lymphocyte-rich, epithelialrich, mixed lymphoepithelial, and spindle cell thymoma. Since then, a number of other classification schemes were introduced by investigators from Japan, France, Germany, and Italy, of which none managed to achieve universal acceptance [2–4]. Because of this circumstance, the World Health Organization (WHO) assembled a panel of experts and, after many years of deliberation, presented their final proposal for the histopathologic classification of thymic
epithelial neoplasms in 1999 . This proposal was iterated, with minor modifications, in the latest WHO publication on the histologic classification of tumors of the lung, pleura, thymus, and heart .